Cases of Bone-only Metastasis in Recurrent Breast Cancer

MAEKAWA Yoko, TAKAO Shintaro, HIROKAGA Koichi, MIKI Mayuko, YOSHIDA Sachiko

doi:10.3919/jjsa.75.1484

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Other Title

再発乳癌における骨単独転移症例の検討
臨床経験再発乳癌における骨単独転移症例の検討
リンショウケイケンサイハツニュウガンニオケルホネタンドクテンイショウレイノケントウ

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While bone metastasis is a common form of initial recurrence following breast cancer treatment, few cases of bone-only metastasis have been reported. Among the 727 patients with recurrent breast cancer who received initial treatment at our hospital between 1993 and May 2012, 110 (15.1%) had bone-only recurrence. For the 76 of these patients who could be investigated, their clinical characteristics were retrospectively evaluated with a focus on the presence or absence of hormone receptor expression and metastases to other organs occurring following bone recurrence. A total of 69.7% of the patients with bone-only recurrence was estrogen receptor (ER)-positive. In ER-positive and -negative patients, respectively, the mean period to bone metastasis was 50.9±30.9 months and 19±42.9 months, and the median period to subsequent detection of metastases to other organs was 29.6 and 19.8 months, indicating a shorter period for ER-negative patients. Survival also tended to be shorter for ER-negative patients. Patients who were ER-negative, those with a short period from surgery to bone metastasis, and those who had liver metastasis were thought to have a poor prognosis following bone metastasis.

Journal

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 75 (6), 1484-1490, 2014

Japan Surgical Association

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