A Case of Nonfunctioning Malignant Pheochromocytoma with Local Recurrence and Distant Metastases Treated by Multidisciplinary Therapy

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  • 転移再発に対し集学的治療を行った非機能性悪性褐色細胞腫の1例
  • 症例 転移再発に対し集学的治療を行った非機能性悪性褐色細胞腫の1例
  • ショウレイ テンイ サイハツ ニ タイシ シュウガクテキ チリョウ オ オコナッタ ヒキノウ ショウワルセイ カッショク サイボウ シュ ノ 1レイ

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A 54-year-old man who underwent distal gastrectomy for early gastric cancer in February 2007 developed a right adrenal tumor about six months later and underwent extirpation of the tumor in October of the year. The histopathological diagnosis was malignant pheochromocytoma. The patient was discharged from the hospital on the 12th postoperative day, but developed allolalia on the 10th day after discharge. Multiple brain metastases were diagnosed. Thereafter metastases to the lung and the ischiorectal fossa appeared. We performed surgical resection and irradiation as local therapies, and, as the general therapy, combined chemotherapy with cyclophosphamide, vincristine, and dacarbazine for about two years. However, he died of aggravation of the multiple brain metastases in October 2010.<BR>The prognosis of pheochromocytoma is often determined by endocrine symptoms due to excessive catecholamine secreted from the metastatic lesions. This paper deals with a case of a patient who was diagnosed with nonfunctioning malignant pheochromocytoma in whom distant metastases of the tumor, especially those to the brain, carried a fatal course that is extremely rare.

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