大腸印環細胞癌の臨床病理学的検討

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  • Clinicopathologic Features of Signet-Ring Cell Carcinoma of the Colon and Rectum

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Nine cases of signet-ring cell carcinoma of the colorectum were compared clinicopathologically with 1893 cases of advanced colorectal cancer of well-differentiated adenocarcinoma. The mean age was 39.1 y for signet-ring cell carcinoma, which was significantly younger than the 60.3 y for well-differentiated adenocarcinoma. The mean tumor size was 6.8cm for signet-ring cell carcinoma, which was larger than the 5.0cm for well-differentiated adenocarcinoma. The depth of invasion was, ss, or more in all of the cases of signet-ring cell carcinoma, and all cases had nodal metastases. Peritoneal dissemination was more frequent for signetring cell carcinoma (67%) than for well-differentiated adenocarcinoma (7.6%). The curative A resection rate for signet-ring cell carcinoma was 22%, which was lower than the 65% for well-differentiated adenocarcinoma. There were no cases of three-year survival for signet-ring cell carcinoma. Therefore, we consider that curative resection and sufficient lymphadenectomy are necessary for this cancer, as well as detection of tumors in the early phase. We expect improvement in the chemoradiotherapy for colorectal signet-ring cell carcinoma.

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