Significance of Circulating Galectin-3 in Patients with Hepato-biliary and Pancreatic Cancer

  • SHIMURA Tatsuo
    Department of Cancer Biology and Electronics, Fukushima Medical University Department of Organ Regulatory Surgery, Fukushima Medical University
  • SHIBATA Masahiko
    Department of Cancer Biology and Electronics, Fukushima Medical University
  • KOFUNATO Yasuhide
    Department of Organ Regulatory Surgery, Fukushima Medical University
  • ISHIGAME Teruhide
    Department of Organ Regulatory Surgery, Fukushima Medical University
  • OKADA Ryo
    Department of Organ Regulatory Surgery, Fukushima Medical University
  • KIMURA Takashi
    Department of Organ Regenerative Surgery, Fukushima Medical University
  • KENJO Akira
    Department of Organ Regenerative Surgery, Fukushima Medical University
  • MARUBASHI Shigeru
    Department of Organ Regenerative Surgery, Fukushima Medical University
  • OHKI Shinji
    Department of Organ Regulatory Surgery, Fukushima Medical University
  • KONO Koji
    Department of Organ Regulatory Surgery, Fukushima Medical University
  • TAKENOSHITA Seiichi
    Department of Organ Regulatory Surgery, Fukushima Medical University

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Other Title
  • 肝胆膵癌における血中galectin-3の意義
  • カンタンスイガン ニ オケル ケッチュウ galectin-3 ノ イギ

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Abstract

Circulating galectin-3 (gal-3) has been reported to induce angiogenetic factors, such as vascular endothelial growth factor (VEGF), intercellular adhesion molecule (ICAM)-1, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), and interleukin (IL)-6. Circulating gal-3, VEGF, G-CSF, and IL-6 concentrations were investigated in patients with hepato-biliary and pancreatic cancer (n = 63), in relation to various nutritional and inflammatory factors, such as retinol binding protein, transferrin, prealbumin, C-reactive protein (CRP), white blood cell count (WBC), and the neutrophil/lymphocyte ratio (NLR). Serum galectin-3 concentrations were significantly higher in patients than in healthy controls (P < 0.001). Circulating gal-3 concentrations were significantly correlated with VEGF, ICAM-1, G-CSF, and NLR concentrations (P < 0.05), whereas they were inversely correlated with IL-12 production (P < 0.05). Circulating gal-3 might have a role in the induction of angiogenetic factors and Th-2-dominant immunological status in hepato-biliary and pancreatic cancer.

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