A Case of Mucosal Prolapse Syndrome (MPS) with Well-Differentiated Adenocarcinoma

  • Iida Naoko
    Department of Surgery, the Jikei University School of Medicine
  • Hada Takenori
    Department of Surgery, the Jikei University School of Medicine
  • Eto Ken
    Department of Surgery, the Jikei University School of Medicine
  • Mitsuyama Yoshinobu
    Department of Surgery, the Jikei University School of Medicine
  • Ikegami Masahiro
    Department of Pathology, the Jikei University School of Medicine
  • Yanaga Katsuhiko
    Department of Surgery, the Jikei University School of Medicine

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Other Title
  • 高分化型腺癌を合併した直腸粘膜脱症候群(MPS:Mucosal Prolapse Syndrome)の1例

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In May 2010, a 38-year-old woman visited a local hospital for evaluation of occult blood in stool, mild anemia and anal bleeding after defecation. As colonoscopy demonstrated serrated polyps at the dentate line, she was referred to our hospital for further evaluation and treatment. The physical examination was unremarkable except for the rectal examination, during which a soft tumor was palpated. As she also had had a “straining” habit for more than ten years, local excision of the lesions was performed with the diagnosis of mucosal prolapse syndrome (MPS). Histopathologically, the rectal mucosa of these lesions exhibited fibromuscular obliteration within the lamina propria, which is characteristic of MPS. Furthermore, a part of one of the two lesions, 11mm in diameter, demonstrated well differentiated adenocarcinoma accompanied by high-grade tubular adenoma. She has been followed for 3 years without any evidence of recurrence.

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