正常妊娠経過中の血液凝固線溶系およびインヒビター系の動態に関する研究

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  • Studies on coagulation-fibrinolysis system in normal pregnancy

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We conducted the present study in the belief that changes in the coagulation-fibrinolysis system during normal pregnancy have a sufficiently great clinical importance.<br> With 30 non-pregnant women as the control, total 270 normal gravidas were observed during pregnancy.<br> Laboratory tests performed were those on the activities of coagulation factors XII, IX, VIII, VII, X, V, II and XIII, platelet counts, Fbg, PLg-Act, pro-Act, PLg, SFMC, FDP, AT-III, C1-INA, α2-PI, α2-M, and α1-AT.<br> The activity of the intrinsic coagulation system was markedly accelerated since the middle stage of pregnancy, while that of the extrinsic system tended to be slightly accelerated in late pregnancy. Factor XIII was diminished, C1-INA decreased, SFMC and FDP elevated. From the above findings, chronic DIC pattern was recognized.<br>In the fibrinolytic system, PLg-Act was markedly diminished pro-Act and PLg gradually elevated, α2-PI and α2-M did not change, and α1-AT increased. These indicated that the fibrinolytic system was depressed on the whole.

収録刊行物

  • 血液と脈管

    血液と脈管 12 (3), 395-398, 1981

    一般社団法人 日本血栓止血学会

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