書誌事項
- タイトル別名
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- Effects of folic acid supplementation on hyperhomocysteinemia in CAPD patients: Effects on unsaturated fatty acids.
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抄録
Hyperhomocysteinemia has been recognized as one of the risk factors for atherosclerosis and premature vascular disease. Patients on dialysis and end-stage renal disease also manifest high plasma concentrations of homocysteine. We performed this study to evaluate the effects of folic acid supplementa tion on hyperhomocysteinemia in CAPD patients. Twenty-three CAPD patients (8 males, 15 females, 49.1±14.2-years-old) dialyzed for 22.7±19.2 months participated in the study. Daily 5-mg doses of folic acid supplementation for 4 weeks significantly reduced plasma concentrations of total homocysteine (p < 0.01) and serine (p < 0.001) . This observation suggests that the reduction of plasma concentrations of total homocysteine results from activation of homocysteine remethylation to methionine. On the other hand, folic acid supplementation also revealed significant correlations between changes in serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid and changes in plasma concentrations of total homocysteine (r = -0.517, p<0.05, r = -0.451, p<0.05, respectively) . In addition, serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid in 11 CAPD patients with hyperhomocysteinemia (≥ 35 micromol/litter) were significantly lower than those of 12 CAPD patients with normohomocys teinemia ( < 35 micromol/litter) (p < 0.05, p < 0.05, respectively). Serum concentrations of both dihomo-γ-linolenic acid and arachidonic acid in CAPD patients with hyperhomocysteinemia increased significantly (p<0.01, p<0.05, respectively) and reached similar levels of CAPD patients with normohomocys teinemia, while plasma concentrations of total homocysteine decreased after folic acid supplementation. These findings suggest that correction of hyperhomocysteinemia in patients on dialysis produces an increase in unsaturated fatt acids.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 40 (1), 8-16, 1998
社団法人 日本腎臓学会
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詳細情報 詳細情報について
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- CRID
- 1390001204857570432
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- NII論文ID
- 130004064212
- 10008361978
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- NII書誌ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- PubMed
- 9513377
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可