脳血管障害患者の血小板および血しょう中セロトニン値

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  • Intraplatelet and plasma serotonin level in cerebrovascular diseases (CVD)

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Intraplatelet serotonin (5-hydroxytryptamine: 5HT) and 5HT in the plasma was assayed spectrophotometrically in 69 healthy volunteers and in 67 patients with cerebrovascular diseases (CVD), including acute cerebral thrombosis within 72 hours of onset (13 cases), chronic cerebral thrombosis during 2 months to 4 years from onset (27), TIA (11), RIND (2), SAH (5), intracerebral hematoma (ICH) (7) and recurrent cerebral thrombosis (2).<br>In health, the intraplatelet 5HT level decreased significantly with increasing age, and plasma 5HT level showed slight increase with age (Fig. 1).<br>In acute cerebral thrombosis, intraplatelet 5HT level was decreased significantly and that of plasma was high compaired to the healthy control at any age group. Chronic cerebral thrombosis, however, showed neither significant decrease in the intraplatelet level nor increase in the plasma. The reversible stroke, such as TIA and RIND, had lower intraplatelet 5HT than that of control, but the plasma level was within normal range. In SAH and ICH as hemorrhagic CVD, either the intraplatelet or plasma 5HT was within normal range. Recurrent cerebral thrombosis stroke under treatment revealed very high level of intraplatelet 5HT (Fig. 2).<br>Under the above sesults, we may conclude that, in acute thrombus forming state, intraplatelet 5HT level was decreased.

収録刊行物

  • 血液と脈管

    血液と脈管 12 (2), 255-259, 1981

    一般社団法人 日本血栓止血学会

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