原発性ネフローゼ症候群の免疫異常　　細胞性免疫，とくにＳｕｐｐｒｅｓｓｏｒ　ｃｅｌｌに関する研究

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タイトル別名
  • Immune Abnormality in Primary Nephrotic Syndrome
  • ゲンパツセイ ネフローゼ ショウコウグン ノ メンエキ イジョウ サイボウセイ
  • ―細胞性免疫,とくにSuppressor cellに関する研究―

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We have studied peripheral blood lymphocytes (PBL) obtained from 35 patients with primary nephrotic syndrome (NS) to determine if there is an abnormality in concanavalin A (Con A)-induced suppressor cell activity compared to control subjects. Suppressor cells were generated by preincubation of PBL or T cells with Con A for 48 hr followed by treatment with mitomycin C. Suppressor cell activity was assessed in the second cultures by inhibition of mitogen-stimulated blast transformation of fresh alloge-neic PBL. Suppressor cell activity was signicantly enhanced (p<0.001) in Patients with NS when comparedd to control subjects. Such increased suppressor cell activity was related to disease activity reflected by urinary findings, but there was no correlation between suppressor cell activity and disease type classified by histological features. In serial studies, the enhanced Suppressor cell activity in patients with NS was normalized along with the complete remission of the disease. When T cells with receptors for the Fc portion of immunolobulin G (T1 cell) were removed from T cell population in partients with NS, normal level of suppressor cell activity was induced. Tγ cells were increased in number in NS patients compared to normal individuals, but no significant differeces were found. There was no change in Tγ cells in remission. These findings suggest that suppressor cell activity plays a key role in the pathogenesis of pri-mary nephrotic syndrome.

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