Observati onson Urinary Fibrinolytic Activity in Various Renal Disease

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  • 各種じん疾患における尿中線溶能に関する研究
  • カクシュ ジン シッカン ニ オケル ニョウチュウ センヨウノウ ニカンスルケ

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Abstract

In order to estimate the role intraglomerular blood coagulation and f ibrinolysis in the progresion of glomerulonephritis, the urinary fibrinolytic activities were examined in 59 cases with various glomerular lesion. The fibrinolytic activities were examined by the fibrin agar plate. The urinary plasminogen a:tivator and the urinary plasmin inhibitor were separated by the affinity chromatography with lysin-sephraroses. The results were as follows, (1) The urinary fibrinolytic activity levels in patieuts with nephrotic syndrome decreased at the acute stage. (2) The urinary plasminogen activator is directly proportional to renal function and so is the urinary plasmin inhibitor to urine protein. (3) The urinary fibrinolytic activity in various glomerular lesion is directly proportional to urinary plasminogen activator, but it has no correlation to plasmin inhibitor. (4) In contrast, the urinary fibrinolytic activity is inversely proportional to the urinary plasmin inhibitor at the acute stage of nephrotic syndrome, It is concluded that as a rule, the urinary f fibrinolytic activity is affected by the urinary plasminogen activator in glomerular lesion, but at the acute stage of nephrotic syndrome, the urinary plasmin inhi-bitor has a certain influence upon urinary fibrinolytic activity.

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