Effect of 1α-Hydroxycholecalciferol on Hypocalcemia and Renal Function of Chronic Renal Failure
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- Takeda Katsuji
- Department of cardiology, Jichi Medical School
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- Kusano Eiji
- Department of cardiology, Jichi Medical School
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- Asano Yasushi
- Department of cardiology, Jichi Medical School
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- Hosoda Saichi
- Department of cardiology, Jichi Medical School
Bibliographic Information
- Other Title
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- 慢性じん不全患者の低カルシウム血症とじん機能に及ぼす1α‐ヒドロキシコレカルシフェロールの影響
- マンセイ ジンフゼン カンジャ ノ テイ カルシウム ケッショウ ト ジン キ
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Abstract
The present study was carried out to evaluate the effect of 1α-hydroxycholecalcif erol (1α-(OH)-D3) on serum free and total calcium, parathyroid hormone, alkaline phosphatase, bone X-P change and renal function in 21 hypocalcemic patients under hemodialysis and 7 non-dialysed patients. 1) 21 hypocalcemic patients under hemodialysis were treated with 1α-(OH)-D3 for 6 months. 1α-(OH)-D3 induced a significant increase in serum calcium concentration after 4 weeks and it reached to normal level after 8 weeks. It also induced a significant reduction of raised serum parathyroid hormone and alkaline phosphatase activity after 16 weeks. No significant changes were obtained in phosphate, creatinine and bone X-P. 2) 7 hypocalcemic non-dialysed patients were also treated by 1α-(OH)-D3 for 4 to 20 weeks against 9 normocalcemic chronic renal failure (control). 1α-(OH)-D3 induced a significant increase in serum calcium and reduction of parathyroid hormone after 16 weeks, It also induced a increase in serum creatinine concentration after 12 weeks which was greater than that of control patients. This result suggests that 1α-(OH)-D3 treatment is noxious to the renal function of chronic renal failure.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 23 (1), 13-25, 1981
Japanese Society of Nephrology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204859238656
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- NII Article ID
- 130004168659
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- NII Book ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL BIB ID
- 2342695
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- PubMed
- 7289202
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed