Maxacalcitolの骨に対する直接効果が示唆された副甲状腺摘除術適応の二次性副甲状腺機能こう進症の1症例

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  • A case with secondary hyperparathyroidism suggesting the direct suppressive effect of maxacalcitol on osteoblasts.

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The direct effect of vitamin D on osteoblasts in secondary hyperparathyroidism (2°HPT) is not necessarily obvious. We found an unusual hemodialyzed patient without any response to oral calcitriol pulse therapy (4μg×2/week), and who was administrated maxacalcitol at a dose of up to 15μg×3/week for 28 months. Plasma intact parathyroid hormone (PTH) was not suppressed from the initial level of 1, 773 pg/ml to 2, 100 pg/ml. However, on the contrary, alkaline phosphatase (ALP) was successively suppressed from 2 weeks from the initial level of 1, 261 IU/l to 276IU/l.

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