A Study on Immune Complex Deposits in Glomeruli of Membranous Nephropathy, Membranoprolif erative Glomerulonephritis and Lupus Nephritis

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  • H. Kawasumi
    Dept. of Internal Medicine, Showa University, School of Med.
  • S. Takase
    Dept. of Internal Medicine, Showa University, School of Med.
  • T. Shibata
    Dept. of Internal Medicine, Showa University, School of Med.
  • K. Saito
    Dept. of Internal Medicine, Showa University, School of Med.
  • J. Uchida
    Dept. of Internal Medicine, Showa University, School of Med.
  • K. Kitazawa
    Dept. of Internal Medicine, Showa University, School of Med.
  • J. Yamamoto
    Dept. of Internal Medicine, Showa University, School of Med.
  • S. Sato
    Dept. of Internal Medicine, Showa University, School of Med.
  • M. Yonekura
    Dept. of Internal Medicine, Showa University, School of Med.
  • S. Ito
    Dept. of Pathology, State University New York at Buffalo, N.Y. U.S.A.
  • S. Shiwachi
    Dept. of Internal Medicine, Showa University, School of Med.
  • K. Kan
    Dept. of Internal Medicine, Showa University, School of Med.
  • T. Sugisaki
    Dept. of Internal Medicine, Showa University, School of Med.

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Other Title
  • 膜性じん症，膜性増殖性じん炎，ループスじん炎におけるじん糸球体沈着抗原抗体結合物の研究
  • マク セイ ジンショウ マク セイ ゾウショクセイ ジンエン ループス ジンエ

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Abstract

The immune process is responsible for many forms of glomerulonephritis in man, but the chracterization of the antigens in glomerular immune complex has been little elucidated. The purpose of this paper is to study the characterization of the immune complex dcposited in glop meruli of membranous nephropathy (M. N.), membranoproliferative glomerulonephritis (MPGN), lupus nephritis, IgA nephropathy and Schöenlein-Henoch purpura (S.H.P.) Nine cases of lupus nephritis, seven cases of MN, two cases of MPGN, seven cases of IgA nephropathy and one case of S.H.P. are studied. Immunof luorescence studies revealed granular IgG deposits of all cases of lupus nephritis, MN and MPGN, and mesangial IgA deposits of all cases of IgA nephropathy and S.H.P. These renal frozen sections are performed dissociation test of IgG from the glomeruli. Renal frozen sections were incubated with human Fr II, human IgG, human IgA, human FxIA, DNA, rabbit Fr II, rat Fr II, and bovine Fr II for 6 hours at room temperature changing in PBS, and then these specimens were stained with FITC-conjugated anti-human IgG or IgA antibody. In all cases of lupus nephritis, MN and MPGN, the IgG deposits in glomeruli disappeared following incubation with human Fr II and human IgG, especially heat aggregated human Fr II. These results suggested that the immune complex deposits in glomeruli of lupus nephritis, MN, and MPGN consisted of the patients own denatured IgG and IgG rheumatoid factor.

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