Heparin Treatment of Disseminated Intravascular Coagulation Syndrome after Open Heart Surgery

DOI Open Access
  • HIRATA Kunihisa
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • YOSHIDA Koji
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • TOKUYASU Toshiyuki
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • NISHIMURA Setsuo
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • NUKI Shuichiro
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • KASAHARA Takashi
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • KAKU Nobuo
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University
  • KOGA Michihiro
    The 2nd Department of Surgery, Faculty of Medicine, Kurume University

Bibliographic Information

Other Title
  • 開心術後のDICに対するヘパリン療法

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Description

In 6 patients with Fallot (4 cases), endocardial cushion defects (1) and annuloaortic ectasia (1), laboratory evidence of the disseminated intravascular coagulation (DIC) syndrome was found at early time after open heart surgery. Though there have been many of the etiologic factors contributing to the production of DIC following cardiopulmonary bypass, in this study polycythemia, low cardiac output or shock and sepsis in addition to a long term bypass and hemolysis due to it complicated the factors.<br>In all patients a bleeding tendency occured. The clinical manifestations of this hemorrhagic diathesis included bleeding from venipuncture sites, petechiae, ecchymoses, hematuria, tracheobroncheal bleeding and gastrointestinal bleeding. 2 patients had peripheral vasoconstriction with peripheral cyanosis. In 2 patients renal failure was found and in one necessitated hemodialysis.<br>All patients were done administration of heparin as well as appropriate therapy of any underlying etiologic factors. 4 of the 6 patients eventually recovered. In laboratory evidence, platelet count, prothrombin time, fibrin degradation products and thrombelastogram returned to normal levels.

Journal

  • Blood & Vessel

    Blood & Vessel 10 (2), 205-209, 1979

    The Japanese Society on Thrombosis and Hemostasis

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