High-dose intravenous gammaglobulin for membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN) and lupus nephritis (LN)
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- SUGISAKI TETSUZO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- SHIWACHI SHGEYO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- ITO SHOGO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- YONEKURA MASAHIRO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- KITAZAWA KOZO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- YAMAMOTO JUN
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- UCHIDA JUN
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- KAWASUMI HISASHI
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- SATO KENICHII
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- SHIBATA TAKANORI
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- TAKASE SHIGERU
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
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- SOEDA KEIKO
- Dept. of Int. Med. Showa Univ. School of Med Tokyo, Japan
Bibliographic Information
- Other Title
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- 膜性腎症,膜性増殖性糸球体腎炎,ループス腎炎に対する大量γ-グロブリン療法
- マク セイ ジンショウ マク セイ ゾウショクセイ シキュウタイ ジンエン ル
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Abstract
Three cases of idiopathic MN, 2 of MPGN and 3 of LN were demonstrated IgG de-posits along glomerular capillary walls in granular pattern and were dissociated after incubation with human γ-globulin. Furthermore, the dissociation of IgG in glomeruli was observed following incubation with plasmin-treated, PEG-treated, sulfonated kuman γ-globulin and Fc fragment, but not with pepsin-treated human γ-globulin, indicating that Fc fragment may play an important role for the dissociation. These results suggest that immune complexes in the glomeruli consist of the patient's own denatured IgG and IgG-RF. On the basis of these findings, all of the patients were treated with large intravenous dose of plasmin-treated γ-globulin (5g/day, 610 times). In all patients the urine protein and/or hematuria rematuria remarkedly decreased or disappeared within 7 days to 40 days. During 60 to 90 days of observation all patients with these renal diseases could be main-tained in improved status from nephrotic syndrome. No untoward effects of γ-globulin therapy were observed. Thus, administration of high-dose intravenous γ-globulin is useful treatment for MN, LN and MPGN.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 25 (6), 697-708, 1983
Japanese Society of Nephrology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204859905024
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- NII Article ID
- 40002959082
- 10005530988
- 130004063731
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- NII Book ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL BIB ID
- 2634166
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- PubMed
- 6198544
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed