- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
An electron microscopic study of circumferential mesangial interposition in various renal diseases.
-
- MARUYAMA Yuuichiro
- Department of Medicine (II), Niigata University School of Medicine
Bibliographic Information
- Other Title
-
- 全周性メサンギウム間入ｃｉｒｃｕｍｆｅｒｅｎｔｉａｌ ｍｅｓａｎｇｉａｌ ｉｎｔｅｒｐｏｓｉｔｉｏｎの超微形態学的研究
Search this article
Description
It has been reported that circumferential mesangial interposition (CMI) is an important mor phological feature suggesting the progression of glomerulosclerosis in glomerular disease. The relation between CMI and its associated lesions was investigated in various renal diseases by electron microscopy. In 276 patients, of whom the glomeruli were observed by electron microscopy, CMI was observed non-specifically in 48 patients with various glomerular diseases (IgA nephropathy, 11; non-IgA glomerulone phritis, 1 ; membranoproliferative glomerulonephritis, 8;membranous nephropathy, 5;lupus glomer ulonephritis, 12;toxemia of pregnancy, 2;diabetic nephropathy, 7;mitomycin nephropathy, 1;and Seckel's dwarfism patients, 1). The glomeruli with CMI showed a marked increase in mesangial matrix, as well as various grades of mesangial cell proliferation. Mesangiolysis associated with subendothelial widening was observed in a lesion of CMI in most cases . This phenomenon appears to be an initial alteration that conducts proliferated cells to the peripheral portion of a capillary loop. Localized severe thinning of the glomerular basement membrane was frequently combined with CMI, particularly in IgA nephropathy patients. Endothelial cells were occasionally interposed into the widened subendothelial space . Subendothelial deposits were noticed in the CMI lesion, particularly in MPGN patients. In conclusion, in the process of glomerulosclerosis progression in various glomerular diseases, lytic and edematous changes initially occur in the mesangao-subendothelial system (mesangiolysis and suben dothelial widening), then proliferating mesangial cells extend into the widened space (between GBM and endothelial cells), and reach the peripheral portion of a capillary loop.
Journal
-
- The Japanese Journal of Nephrology
-
The Japanese Journal of Nephrology 40 (4), 263-275, 1998
Japanese Society of Nephrology