Clinical application of a synthetic vasopressin 1-deamino-8-D-arginine vasopressin, DDAVP

DOI Open Access
  • KOBAYASHI Isao
    Second Department of Internal Medicine, Yamanashi Medical College
  • TAMURA Kohji
    Second Department of Internal Medicine, Yamanashi Medical College
  • HATTORI Akira
    First Department of Internal Medicine, Niigata University School of Medicine
  • TAKAHASHI Hoju
    First Department of Internal Medicine, Niigata University School of Medicine
  • SANADA Masayoshi
    First Department of Internal Medicine, Niigata University School of Medicine
  • SHIBATA Akira
    First Department of Internal Medicine, Niigata University School of Medicine

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Other Title
  • 合成バソプレシン１‐ｄｅａｍｉｎｏ‐８‐Ｄ‐ａｒｇｉｎｉｎｅ　ｖａｓｏｐｒｅｓｓｉｎ（ＤＤＡＶＰ）の臨床応用　　ＤＤＡＶＰの正常ヒト血小板機能におよぼす影響について
  • DDAVPの正常人血小板機能におよぼす影響について

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Description

Recently a synthetic vasopressin DDAVP is used for hemostatic control of hemophiliacs. The hemostatic mechanism of DDAVP in hemophilia A and von willebrand's disease is understandable because of the increment of factor VIII activity and von Willebrand factor, but in hemophilia B the mechanism is yet unclear. The influence of DDAVP on platelet function in normal subjects was studied to clarify the hemostatic mechanism.<br>Eight μg of DDAVP was injected intravenously to fifteen normal subjects and VIII: C, VIIIR: WF, aPTT, platelet count, prothrombin consumption, platelet adhesion (Hellem II method), platelet aggregation induced by ADP, adrenaline, collagen and ristocetin, platelet shape and platelet factor 3 were measured before and after (one and two hours) the injection.<br>VIII: C and VIIIR: WF increased by 2.5 and 1.5 times, respectively (p<0.001). Increase of prothrombin consumption rate (p<0.002) and platelet adhesion rate (p<0.01) was statistically significant. APTT also shortened (p<0.001) and platelet aggregation induced by a low concentration of ristocetin (1mg/ml) increased in 11 out of 15 cases. In platelet shape study only the pseudopod increased significantly (p<0.01).<br>The accerelation of prothrombin consumption and platelet adhesion may be induced by the increase of VIII: C and VIIIR: WF, and DDAVP seems not to give any direct effects on platelet function in normal subjects.

Journal

  • Blood & Vessel

    Blood & Vessel 13 (1), 44-51, 1982

    The Japanese Society on Thrombosis and Hemostasis

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