ウロキナーゼ固定化材質の抗血栓性発現機序について

DOI 被引用文献1件

書誌事項

タイトル別名
  • The mechanism of antithrombogenicity of urokinase immobilized polyurethane - Effects on platelet adhesion.
  • effects on platelet adhesion

この論文をさがす

抄録

Urokinase (UK) immobilized material is known to have excellent antithrombogenicity. This antithrombogenicity has been ascribed to the fibrinolytic activity of plasmin activated by UK.<br>We found that platelet adhesion was not recognized on the surface of UK immobilized polyurethane catheter indwelled in vein. To investigate the interaction between platelet adhesion and fibrinolytic activity, inactivated immobilized UK was prepared by chemical modification with (p-amidinophenyl) methanesulfonyl fluoride hydrochloride. Polyurethane, UK immobilized polyurethane and inactivated UK immobilized polyurethane were incubated with human blood in Chandler loop and their surface were observed by scanning electronmicroscopy. Platelet adhesion on the surface of the material was recognized for polyurethane but not observed for UK immobilized polyurethane and inactivated UK immobilized polyurethane.<br>We concluded that the antithrombogenicity of UK immobilized material depends not only on fibrinolytic activity but also inhibition of platelet adhesion which is not mediated with plasminogen activation by urokinase.

収録刊行物

  • 血液と脈管

    血液と脈管 18 (3), 264-266, 1987

    一般社団法人 日本血栓止血学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ