- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
A case of Wegener's granulomatosis showing a dramatic response to corticosteroid and cyclophosphamide therapy
-
- HIRANO KIYOSHI
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
-
- TOMINO YASUHIKO
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
-
- MURAI TOSHIO
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
-
- WANG LI NING
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
-
- SHIRATO ISAO
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
-
- KOIDE HIKARU
- Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine
Bibliographic Information
- Other Title
-
- —Evaluation of anticytoplasmic antibodies (ACPA) in serum samples—
Search this article
Description
A case of Wegener's granulomatosis with renal dysfunction is described. Granulomatous lesions of the lung, left eyelid and left leg, and chronic sinusitis were observed at the time of admission. Renal and skin biopsy specimens revealed typical features of Wegener's granulomatosis on light microscopy and immuno fluorescence microscopy. A dramatic response occurred following cortico steroid and cyclophosphamide therapy, characterized by improvement of proteinuria and renal function, and disappearance of the granulomas and 67gallium citrate accumulations in both the eyes and nose. Further-more, the levels of anticytoplasmic antibodies (ACPA) in the serum samples were significantly decreased after such therapy. It appears that combined therapy with corticosteroid and cyclophosphamide can be effective in improving proteinuria and renal dysfunction, and in reducing of ACPA in patients with Wegener's granulomatosis.
Journal
-
- The Japanese Journal of Nephrology
-
The Japanese Journal of Nephrology 32 (3), 339-344, 1990
Japanese Society of Nephrology