書誌事項
- タイトル別名
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- Evaluation of urinary factor H excretion in patients with idiopathic membranous nephropathy
- トクハツセイ マクセイ ジンショウ ニ オケル ニョウチュウ FactorH ハイセツリョウ ノ スイイ ニ カンスル ケントウ
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Background: The complement system plays an important role in renal pathogenesis, and C5b-9, a terminal complement complex, is regarded as the principal mediator of proteinuria in idiopathic membranous nephropathy (MN). Since factor H regulates complement activation at the C3 step and is a crucial factor in complement-mediated tissue injury, the urinary excretion of factor H in patients with idiopathic MN was investigated.<br>Methods: Seven patients with biopsy-proven idiopathic MN were studied for twenty-four weeks. Urinary factor H levels were measured by ELISA from regularly collected urine samples, and then evaluated and compared with assays of urinary protein and C5b-9 excretion.<br>Results: During the study, five patients were treated with steroid therapy. All seven patients maintained stable renal function and showed a decline in urinary protein excretion. The mean level of urinary factor H was markedly elevated (156.1±47.1U/mg U-Cr) before treatment (0 week), and gradually declined to 127.2±43.5U/mg U-Cr at 12 weeks, and to 64.7±26.9U/mg U-Cr) at 24 weeks. This followed decreases in urinary protein and urinary C5b-9 excretion. Percent change in urinary factor H level significantly decreased 24 weeks after treatment without affecting the plasma factor H level.<br>Conclusion: These results suggest that factor H contributes to the regulatory mechanism of in situ complement activation, and thus the study of urinary factor H levels, as well as urinary C5b-9, may be significant in idiopathic MN.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 49 (5), 499-504, 2007
社団法人 日本腎臓学会
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詳細情報 詳細情報について
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- CRID
- 1390001204861207936
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- NII論文ID
- 130004170818
- 10019813678
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- NII書誌ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL書誌ID
- 8913037
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可