A Study of Serum Carcinoembryonic Antigen in Uremic Patients on Hemodlalysis

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  • Kodama Takaya
    2nd Department of Surgery, Faculty of Medicine, University of Tokyo
  • Fujino Masayuki
    1st Department of Medicine, Faculty of Medicine, University of Tokyo
  • Endo Yasuo
    1st Department of Medicine, Faculty of Medicine, University of Tokyo
  • Otsubo Osamu
    Department of Organ Transplantation and Physiology, Institute of Medical Science, University of Tokyo
  • Otsubo Kimiko
    Department of Organ Transplantation and Physiology, Sangenjaya Hospital
  • Masaka Michiko
    Division of Endocrinology, Kitasato Biochemical Laboratories (Bristol Lab.), Kitasato University Hospital
  • Sato Seiya
    Division of Endocrinology, Kitasato Biochemical Laboratories (Bristol Lab.), Kitasato University Hospital
  • Wada Tatsuo
    2nd Department of Surgery, Faculty of Medicine, University of Tokyo

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Other Title
  • 血液透析患者における血清中CEAに関する研究
  • ケツエキ トウセキ カンジャ ニ オケル ケッセイチュウ CEA ニカンスルケ

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Serum carcinoembryonie antigen (CEA) of 133 uremic patients on hemodialysis was assayed by sandwich method of Nishi and Hirai, and moderate increase of serum CEA (2.57 ± 0.11 ng/ml, [mean ± standard error]) was found. Among those patients, significant increase of serum CEA levels was found in cigarette smokers and aged groups. High serum CEA was significantly more frequent in blood group O and B than in blood group A. In 67 of them, their serum CEA levels were compared with the history of hemodialysis, 24-hour urinary volume and various laboratory data. No significant relations were found between those and serum CEA levels. The general increase of serum CEA in uremic patients was not explainable solely by smoking, age and blood groups. It may be due to inability to excrete CEA-like substances into urine in these patients.

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