腸管におけるK輸送に関する研究(代償性K排泄機能とその因子について)

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タイトル別名
  • Study on Potassium Transport in the Intestine Compensatory Potassium Excretion Mechanism Increasing Factors of Potassium Secretion
  • チョウカン ニ オケル K ユソウ ニカンスルケンキュウ ダイショウセイ K

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The perfusion experiment was performed to clarify the mechanism of potassium transport and factors of regulating potassium secretion in the rat intestine. Na and K equilibrium concentration, electrical potential difference (PD) and fecal Na and K contents were measured. In addition, Na and K balance study were carried out in patients with chronic uremia. The following results were obtained. 1) In the control rat, chronic potassium load increased potassium secretion, sodium absorptionn and PD in the colon, whereas no changes were observed in the jejunum and ileum, Fecal Na/K ratio was also decreased by potassium load. 2) K net flux was similar in the rat small intestine of control and experimental renal failure (RF). 3) In the colon of RF rat, chronic potassium load increased potassium secretion, sodium absorption and PD, which suggests a same mechanism for potassium secretion process in the colon of normal rat with potassium load. This potassium secretion rate fell when Na-free choline chloride solution was perfused. Increased potassium secretion in the colon was inhibited by spironolactone and this results suggest that potassium secretion in the colon is mediated by aldosterone. Fecal excretion of potassium in the RF rat plays an important role in maintaining potassium balance. 4) Aldosterone increased potassium secretion, sodium absorption and PD in the colon of adrenalectomized rat, but no effect was observed in the jejunum and ileum. Increased fecal excretion of potassium and decreased fecal Na/K ratio were also found. These data suggests that aldosterone plays an important role in regulating potassium secretion in the colon. 5) Increased fecal potassium excretion indicates an important extra-renal excretory pathway for the purpose of maintaining potassium balance in patients with renal failure.

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