The effects of hen-egg lysozyme on Masugi nephritis and Aminonecleoside nephropathy

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  • Sugisaki Tetsuzo
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Ito Shogo
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Sato Shigeru
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Shiwachi Shigeyo
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Yonekura Masahiro
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Kitazawa Kozo
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Yamamoto Jun
    Dept. of Internal Medicine, School of Medicine, Showa University
  • Uchida Jun
    Dept. of Internal Medicine, School of Medicine, Showa University

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Other Title
  • 塩化リゾチームの馬杉腎炎並びにアミノヌクレオサイド腎症に対する影響
  • エンカ リゾチーム ノ バスギ ジンエン ナラビニ アミノヌクレオサイド ジン

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Abstract

Lysozyme (Ly.) has been ordinary known as anticoagulant agent, antiinflammatory agent and a agent possessing recovering function from the tissue injury. On such pharmacological basis of this drug, we studied the effect of hen-egg Ly. (kindly supplied by Nippn-Shinyaku Co. L.T.D.) on Masugi nephritis and Aminonucleoside nephropathy in rats. Regarding with the effects of Ly. on acute phase of Masugi nephritis, the degree of infiltration of polymorphonuclear leucocytes (PMN) became severe with the increase of the dose. Although fibrin deposition in glomeruli was slight in the groups rate received 60 mg Ly. per rat, there were no distinctive difference between the experimental other groups and control group. Regarding with the effect of Ly. on chronic phase of Masugi nephritis, massive proteinuria was found in all groups without any correlation due to the dosis. On the microscopical findings, all groups of rats with Masugi nephritis showed proliferative and partially hyalinized glomeruli, interstitial mononuclear cell infiltration and degenerative tubular changes. The degree of fibrin deposits seemed to be increased in the groups of rats received Ly., comparing with the control group. Regarding with the effects of Ly. on Aminonucleoside nephropathy, experimental rats developed fairly large amount of proteinuria on 12 th day after Aminouucleoside injection. But no significant difference on the proteinuria was found in all groups of rats. In addition of this, light microscopical findings in all groups similarly showed widening of mesangial area, mild proliferative changes in glomeruli, degenerative tubular changes and interstitial mononuclear cell infiltration, but the degree of fibrin deposition seemed to be severe in the groups of rat received Ly. From these results, the effect of Ly, on the glomerular injury induced by immunological or nonimmunological procedure seemed to have enhancing action against the infiltration of PMN and also coagulation process. Thus, it was suggested that Ly, was of the inductive action for scarring and healing effects of injury site.

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