Distributions of Steroid 5.ALPHA.-Reductase and 17.ALPHA.-Hydroxylase/C17,20-lyase (P450c17) Immunoreactivities in Rat Gastric Mucosa

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  • Yokoi Hiromichi
    Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School Kagawa National Children's Hospital
  • Tsuruo Yoshihiro
    Departmemt of Anatomy and Cell Biology, Wakayama Medical University School of Medicine
  • Kominami Shiro
    Faculty of Integrated Arts and Sciences, Material and Life Sciences, Hiroshima University
  • Yamazaki Takeshi
    Faculty of Integrated Arts and Sciences, Material and Life Sciences, Hiroshima University
  • Ishimura Kazunori
    Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School

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We examined the immunohistochemical localization of steroid 5α-reductase type 1 and 17α-hydroxylase/C17,20-lyase (P450c17) in rat gastric mucosa. Immunoreactivity of 5α-reductase was localized in the chief cells and the mucous neck cells. P450c17 immunoreactivity was localized in the parietal cells. Subcellular localizations of both 5α-reductase and P450c17 were on the membrane of endoplasmic reticulum. P450c17 is a key enzyme of androgen biosynthesis, and 5α-reductase has a high affinity for testosterone and catalyzes the conversion of testosterone to its 5α-reduced metabolite. Thus, it is suggested that there is an androgenic metabolic pathway in rat gastric mucosa.<br>

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