Studies on the Carbohydrate Metabolism in Renal Failure

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  • Kobayashi Kaizo
    Nagoya University Branch Hospital Department of Internal Medicine
  • Shibata Masao
    Nagoya University Branch Hospital Department of Internal Medicine
  • Kato Katsumi
    Nagoya University Branch Hospital Department of Internal Medicine
  • Nakamura Shinya
    Nagoya University Branch Hospital Department of Internal Medicine
  • Kato Shigenobu
    Nagoya University Branch Hospital Department of Internal Medicine
  • Kurachi Kentaro
    Nagoya University Branch Hospital Department of Internal Medicine
  • Imai Tsuneki
    Nagoya University Branch Hospital Department of Internal Medicine
  • Maeda Kenji
    Nagoya University Branch Hospital Department of Internal Medicine
  • Yasuda Bunji
    Nagoya University Branch Hospital Department of Internal Medicine
  • Ota Kazuhiro
    Nagoya University Branch Hospital Department of Internal Medicine
  • Tomino Masanobu
    Nagoya University Branch Hospital Department of Internal Medicine
  • Kawaguchi Syunsuke
    Nagoya University Branch Hospital Department of Internal Medicine
  • Shimizu Kiyoshi
    Nagoya University Branch Hospital Department of Internal Medicine
  • Sasa Ryoji
    Nagoya University Branch Hospital Department of Internal Medicine
  • Tsutsui Syuichi
    Nagoya University Branch Hospital Department of Internal Medicine
  • Yamazaki Chikao
    Nagoya University Branch Hospital Department of Internal Medicine
  • Manji Tadatomi
    Nagoya University Branch Hospital Department of Internal Medicine
  • Nomura Takehiko
    Nagoya University Branch Hospital Department of Internal Medicine
  • Yamashita Koichi
    Nagoya University Branch Hospital Department of Internal Medicine

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Other Title
  • 腎不全における糖質代謝に関する研究
  • ジンフゼン ニ オケル トウシツ タイシャ ニ カンスル ケンキュウ

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Abstract

The blood sugar levels and serum IRI (immunoreactive insulin) levels during the 50 g oral glucose tolerance test, were measured to investigate clinically the glucose metabolism in renal failure. Also, the effects on these levels during ordinary hemodialysis and with xylitol dialysate or glucose-free dialysate, were observed. The results were as follows.1) The 50 g oral glucose tolerance test of the patients treated without dialysis revealed higher blood sugar levels than the ones of the patients treated by hemodialysis.2) The serum IRI and FBS levels or the patients treated without dialysis were higher than the levels of those treated by dialysis.3) The blood sugar levels and serum IRI levels increased when the concentration of glucose in the dialysate was increased.4) The serum blood sugar level and IRI level did not fluctuate during dialysis with glucose-free or xylitol dialysate.5) The effects of dialysis on BUN, serum creatinine, uric acid, and the effects on the concentration of electrolytes and on the acid base balance were similar with three dialysates. The clinical data suggest that it would be better to use glucose-free dialysate or xylitol dialysate, when patients with a carbohydrate abnormality due to severe renal failure or with diabetes mellitus, are Treated by hemodialysis.

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