Studies on the Carbohydrate Metabolism in Renal Failure

Kobayashi Kaizo, Shibata Masao, Kato Katsumi, Nakamura Shinya, Kato Shigenobu, Kurachi Kentaro, Imai Tsuneki, Maeda Kenji, Yasuda Bunji, Ota Kazuhiro, Tomino Masanobu, Kawaguchi Syunsuke, Shimizu Kiyoshi, Sasa Ryoji, Tsutsui Syuichi, Yamazaki Chikao, Manji Tadatomi, Nomura Takehiko, Yamashita Koichi

doi:10.14842/jpnjnephrol1959.13.473

The blood sugar levels and serum IRI (immunoreactive insulin) levels during the 50 g oral glucose tolerance test, were measured to investigate clinically the glucose metabolism in renal failure. Also, the effects on these levels during ordinary hemodialysis and with xylitol dialysate or glucose-free dialysate, were observed. The results were as follows.1) The 50 g oral glucose tolerance test of the patients treated without dialysis revealed higher blood sugar levels than the ones of the patients treated by hemodialysis.2) The serum IRI and FBS levels or the patients treated without dialysis were higher than the levels of those treated by dialysis.3) The blood sugar levels and serum IRI levels increased when the concentration of glucose in the dialysate was increased.4) The serum blood sugar level and IRI level did not fluctuate during dialysis with glucose-free or xylitol dialysate.5) The effects of dialysis on BUN, serum creatinine, uric acid, and the effects on the concentration of electrolytes and on the acid base balance were similar with three dialysates. The clinical data suggest that it would be better to use glucose-free dialysate or xylitol dialysate, when patients with a carbohydrate abnormality due to severe renal failure or with diabetes mellitus, are Treated by hemodialysis.

Studies on the Carbohydrate Metabolism in Renal Failure

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