Metabolic Studies on the Nephrotic Syndrome

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  • Kido Chimoto
    The 2nd Department of Internal Medicine, Niigata University School of Medicine

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Other Title
  • ネフローゼ症候群の病態生理学的研究
  • ネフローゼ ショウコウグン ノ ビョウタイ セイリガクテキ ケンキュウ 3 アミノヌクレオシッドネフローゼ ニ オケル シシツ タイシャ ト トウシツ タイシャ ノ カンレン ニ ツイテ
  • III. On Correlation cf Lipid Metabolism with Carbohydrate Metabolism in Aminonucleoside Nephrosis
  • 第3報　アミノヌクレオシッドネフローゼにおける脂質代謝と糖質代謝の関連について

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In order to investigate patho-physiology of the nephrotic syndrome, the author made on examination of lipid, energy and carbohydrate metabolism, with priority to liver, by using the experimental nephrotic rats induced by aminonucleoside (AN). The resalts were as follows 1) In the AN nephrotic rats, the significant increase in serum cholesterol, esterified fatty acid, and phospholipid were observed, although these lipid concentration in the livers were nearly unchanged. The incorporation with acetate-1-C14 into cholesterol, glucose-U-C14 into fatty acid, and NaHP32O4 into phospholipid respectively, in the liver slices, increased in the nephrotic rats injected nine times with AN, and the synthesis of these lipids in the liver was considered highly increasing. 2) O2 Consumpsion of the substrates in the liver slices generally increased in the nephrotic rats and the result suggested increasing energy metabolism in the nephrotic syndrome. 3) The content of glycogen in the livers and muscles decreased in the nephrotic rats at the time of taking food freely as well as after five hours fasting, and showed a tendency to decrease even after the administration of a certain quantitative of glucose, and the similar decreasing tendency was also seen in the blood sager. In the nephrotic rats, hypoglycemic state was clearly observed. The ratio yields of C14O2 from glucose-6-C14 to that from glucose-1-C14 in the slice of liver showed a tendency to decreased in the nephrotic rats and the above-mentioned fact suggested the possibility of increasing lipogenesis. By investigating the activity of glycolytic enzymes, the author observed that G-6-ease and MDH significantly decreased in the nephrotic group, while LDH strikingly increased. There were no significant differences in PG iso, PG mut, ALD, G6PD, and ICD. From the enzymological level, the existence of lipogenic pattern could not be concluded.

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