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- Saito A.
- Nagoya University Branch Hospital
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- Yamamoto A.
- Nagoya University Branch Hospital
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- Shimizu K.
- Nagoya University Branch Hospital
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- Kawaguchi S.
- Nagoya University Branch Hospital
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- Maeda K.
- Nagoya University Branch Hospital
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- Kobayashi K.
- Nagoya University Branch Hospital
Bibliographic Information
- Other Title
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- 慢性腎不全の窒素代謝に関する研究
- マンセイ ジンフゼン ノ チッソ タイシャ ニカンスルケンキュウ 1 チッソ
- —Nitrogen Balance and <SUP>15</SUP>N Tracing Study with <SUP>15</SUP>N-urea Administration—
- 第一報;窒素出納と<SUP>15</SUP>N-尿素の動態を中心として
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Abstract
Nitrogen balance and m15N incorporation into plasma protein and m15N excretion into urine by intravenous administration of 1 gm Nm15-urea were studied over 1 to 2 weeks on 7 non-dialysed patients with chronic renal failure and 7 dialysed patients. Four of the 7 non-dialysed patients were taking low protein diet (Group A) and 3 on low protein diet with addition of essential amino acids (Group B). Of the 7 dialysed patients, 2 were on single pass system (Group C), 2 on 30L dialysate supply system with adsorbents (Group D), and 3 on 10L dialysate supply system with adsorbents (Group E) Nitrogen balance of Group A was remarkably negative, -1.71gm/day and Group B, slightly positive, +0.27gm/day. All dialysed patients of Group C, D, and E showed slightly positive balance, +0.51, +0.63, and +0, 30 respectively, The mean of the highest values of the m15N incorporation into plasma protein in Group A was 0.017 atom % excess, whereas a normal adult on normal diet showed no 15N incorporation at all. The values for patients Group C, D, and E were positive of 0.012, 0.025, and 0.014 atom % excess respectively. The results indicate that reutilization of urea nitrogen into protein synthesis is increased not only in non-dialysed patients with chronic renal failure taking low protein diet but also in dialysed patients taking high protein diet.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 19 (3), 165-176, 1977
Japanese Society of Nephrology
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Details 詳細情報について
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- CRID
- 1390001204863140480
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- NII Article ID
- 130004168283
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- NII Book ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL BIB ID
- 1817465
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- PubMed
- 560578
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed