PGC-1α mRNA level and oxidative capacity of the plantaris muscle in rats with metabolic syndrome, hypertension, and type 2 diabetes
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- Nagatomo Fumiko
- Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
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- Fujino Hidemi
- Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences
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- Kondo Hiroyo
- Department of Food Sciences and Nutrition, Nagoya Women’s University
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- Gu Ning
- Department of Life Science and Engineering, Harbin Institute of Technology
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- Takeda Isao
- Department of Physical Therapy, Kinjo University
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- Ishioka Noriaki
- Department of Space Biology and Microgravity Sciences, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
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- Tsuda Kinsuke
- Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
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- Ishihara Akihiko
- Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
書誌事項
- タイトル別名
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- PGC-1.ALPHA. mRNA Level and Oxidative Capacity of the Plantaris Muscle in Rats with Metabolic Syndrome, Hypertension, and Type 2 Diabetes
説明
We examined the fiber profiles and the mRNA levels of peroxisome proliferator-activated receptors (PPARα and PPARδ/β) and of the PPARγ coactivator-1α (PGC-1α) in the plantaris muscles of 15-week-old control (WR), metabolic syndrome (CP), hypertensive (SHR), and type 2 diabetic (GK) rats. The deep regions in the muscles of SHR and GK rats exhibited lower percentages of high-oxidative type I and IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR and CP rats. The surface regions in the muscles of CP, SHR, and GK rats exhibited lower percentages of high-oxidative type IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR rats. The muscles of SHR and GK rats had lower oxidative enzyme activity compared with WR rats. The muscles of SHR rats had the lowest PPARδ/β mRNA level. In addition, the muscles of SHR and GK rats had lower PGC-1α mRNA level compared with WR and CP rats. We concluded that the plantaris muscles of rats with hypertension and type 2 diabetes have lower oxidative capacity, which is associated with the decreased level of PGC-1α mRNA.<br>
収録刊行物
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- Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ
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Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 44 (2), 73-80, 2011
日本組織細胞化学会
