Depressed natural killer(NK) function in blood and marrow is related to the decrease in CD 11+ cells in acute leukemia.
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- MORIKAWA Keiko
- The First Department of Internal Medicine, Shimane Medical University
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- NAKANO Akinobu
- The First Department of Internal Medicine, Shimane Medical University
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- OSEKO Fumimaro
- The First Department of Internal Medicine, Shimane Medical University
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- MORIKAWA Shigeru
- Department of Pathology, Shimane Medical University
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説明
The natural killer (NK) cell activity of the blood and marrow was studied in patients with acute myelogenous leukemia (AML). NK activity of the cells from blood and marrow was significantly decreased in AML to three target cell lines. Both binding and killing capacities of the effector cells were deeply depressed in the blood as well as in the marrow at single cell assay. Surface phenotypic analysis showed a significant decrease in CD 11+ cell subsets, but not in CD 16+ or Leu-7+ cells, in both blood and marrow cells from AML. A significant decrease of large granular lymphocytes (LGL) was also displayed in these samples at morphological examination. The effector cells from AML patients poorly responded to interferon stimulation in NK cytolysis. Taken together, a decrease in CD 11+ cell population with LGL morphology appeared to be responsible for the impaired NK activity in patients with AML.
収録刊行物
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- Japanese Journal of Medicine
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Japanese Journal of Medicine 28 (4), 485-491, 1989
社団法人 日本内科学会