An Autopsy Case of Acute Pulmonary Toxicity Associated with Gemcitabine

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  • Autopsy Case of Acute Pulmonary Toxicity Associated with Gemcitabine

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Abstract

Acute respiratory distress syndrome (ARDS) developed following intravenous gemcitabine monotherapy in a 75-year-old man with non-small cell lung cancer. The total dose of gemcitabine was 1, 500 mg, and the latent period from starting gemcitabine to pulmonary toxicity was three days. The chest radiographs and high resolution computed tomographic scan revealed bilateral groundglass opacity. He died on the fourteenth post-chemotherapeutic day due to respiratory failure. Postmortem examination of the lung revealed mixed exudative and fibrotic stages of diffuse alveolar damage. Pulmonary toxicity from gemcitabine can be acute and fatal.<br>(Internal Medicine 42: 1022-1025, 2003)

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  • Internal Medicine

    Internal Medicine 42 (10), 1022-1025, 2003

    The Japanese Society of Internal Medicine

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