Slowly Progressive Dystonia Following Central Pontine and Extrapontine Myelinolysis.

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A 28-year-old woman was hospitalized with dysarthria and oro-mandibular and upper limb dystonia. Approximately 8 years prior to the current admission, the woman became severely hyponatremic due to traumatic subarachnoid hemorrhage-related SIADH. Brain MRIs showed a signal increase in the central pons, thalamus and striatum on T2 weighted images compatible with central pontine and extrapontine myelinolysis. From a few months after that event, dystonia progressed slowly over the subsequent 8 years. We speculate that the particular damage chiefly to the myelin structures by myelinolytic process may have caused an extremely slow plastic reorganization of the neural structures, giving rise to progressive dystonia.<br>(Internal Medicine 39: 956-960, 2000)

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  • Internal Medicine

    Internal Medicine 39 (11), 956-960, 2000

    一般社団法人 日本内科学会

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