Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis.

DOI Web Site Web Site PubMed 2 Citations 30 References
  • HORIE Shiro
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • OKUBO Yoshio
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • HOSSAIN Mahboob
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • SATO Etsuro
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • NOMURA Hiroshi
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • KOYAMA Sekiya
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • SUZUKI Jun-ichi
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • ISOBE Mitsuaki
    The First Department of Internal Medicine, Shinshu University School of Medicine
  • SEKIGUCHI Mode
    The First Department of Internal Medicine, Shinshu University School of Medicine

Bibliographic Information

Other Title
  • Interleukin 13 but Not Interleukin 4 Pr

Search this article

Abstract

The effects of recombinant human (rh) interleukin (IL)-4 or rhIL-13 on survival, and chemotactic activity of human eosinophils were examined. Only rhIL-13 prolonged eosinophil survival in a dose-dependent manner above 3 ng/ml. Eosinophil survival induced by rhIL-13 was inhibited by monoclonal antibodies (mAbs) against IL-3 (p<0.01) and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p<0.05), suggesting that rhIL-13 induced IL-3 and GM-CSF production from eosinophils and an autocrine mechanism is responsible for the eosinophil survival. The effects of rhIL-13 on eosinophil chemotactic activity were also examined. rhIL-13 showed chemotactic activity for eosinophils in a dose-dependent manner. Checkerboard analysis revealed that eosinophil migration was dependent on the concentration gradient, confirming that rhIL-13 is a chemotactic factor. rhIL-4 showed no effects. IL-13 may play an important role in the survival and recruitment of eosinophils in allergic diseases.<br>(Internal Medicine 36: 179-185, 1997)

Journal

  • Internal Medicine

    Internal Medicine 36 (3), 179-185, 1997

    The Japanese Society of Internal Medicine

Citations (2)*help

See more

References(30)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top