Association of Human Leukocyte Antigen Class II Genes with Autoantibody Profiles, but not with Disease Susceptibility in Japanese Patients with Systemic Sclerosis.

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  • KUWANA Masataka
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • INOKO Hidetoshi
    The Division of Molecular Life Science, Department of Genetic Information, Tokai University School of Medicine
  • KAMEDA Hideto
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • NOJIMA Takaki
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • SATO Shinji
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • NAKAMURA Kunio
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • OGASAWARA Takashi
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • HIRAKATA Michito
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • OHOSONE Yasuo
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • KABURAKI Junichi
    The Department of Internal Medicine, Tokyo Electric Power Company Hospital
  • OKANO Yutaka
    The Department of Internal Medicine, Nippon Kokan Hospital
  • MIMORI Tsuneyo
    The Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine

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  • Association of Human Leukocyte Antigen Class 2 Genes with Autoantibody Profiles,but not with Disease Susceptibility in Japanese Patients with Systemic Sclerosis

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Object: To examine the role of human leukocyte antigen (HLA) class II genes in the development of systemic sclerosis (SSc) as well as in the clinical and serologic expression of SSc in patients.<br> Methods: HLA-DRB1, DRB3, DRB4, DQB1, and DPB1 alleles were determined by genotyping; and serum antinuclear antibodies were identified using indirect immunofluorescence, double immunodiffusion and immunoprecipitation.<br> Patients: One hundred and five Japanese patients with SSc and 104 race-matched healthy controls.<br> Results: Frequencies of DRB1 and DQB1 alleles were not different between SSc patients and healthy controls, while DPB1*0901 was marginally increased in SSc patients. In contrast, SSc-related autoantibodies were closely associated with the clinical features. HLA class II genes were detected as follows: anti-DNA topoisomerase I antibody with diffuse cutaneous involvement, pulmonary fibrosis, and DRB1*1502-DQB1*0601-DPB1*0901; anti-U1RNP antibody with overlapping features of lupus and/or myositis and DRB1*0401/*0802-DQB1*0302; and anticentromere antibody with limited cutaneous involvement and DRB1*0101-DQB1*0501-DPB1*0402. In the analysis of the association of HLA class II and the clinical features in SSc patients significant differences were obtained only for the increased frequencies of arthritis and rheumatoid factor in patients with DRB1*0405 compared to those without.<br> Conclusion: HLA class II genes strongly influence the production of SSc-related autoantibodies rather than the development of SSc. In addition, SSc is a composite disease of distinctive subsets defined by serum autoantibodies, which have specific clinical and HLA class II associations.<br>(Internal Medicine 38: 336-344, 1999)

Journal

  • Internal Medicine

    Internal Medicine 38 (4), 336-344, 1999

    The Japanese Society of Internal Medicine

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