Studies on Platelet Functions of Patients with Thrombasthenia

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  • RYO Ryukichi
    The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
  • YASUNAGA Kojiro
    The First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

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  • With Special Reference to the Effects of Prostaglandin E<sub>2</sub> on Platelet Aggregation and Serotonin Release

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Four patients with thrombasthenia have been investigated. All patients showed impaired platelet aggregation by ADP, epinephrine and collagen, decreased platelet adhesiveness, and deficient clot retraction. In all the patients, however, platelet serotonin release induced by collagen was normal. In addition, arachidonate caused an induction of serotonin release in thrombasthenic platelets, although the degree of the release was markedly diminished in 2 patients. Platelets of these patients contained normal amounts of ADP, serotonin and c-AMP. PGE2 failed to augment platelet aggregation by ADP and collagen in these patients. In contrast, PGE2 slightly enhanced platelet serotonin release induced by collagen in 2 patients, but had no effect in others. Thus PGE2 is not considered to be useful for the treatment of bleeding in patients with thrombasthenia.

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