Studies on the Mechanisms of Serum Gamma-Glutamyl Transpeptidase Elevation in Hepatobiliary Disorders
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- FUJISAWA Kiyoshi
- The First Department of Internal Medicine, Jikei University School of Medicine
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- KURIHARA Nobuo
- The First Department of Internal Medicine, Jikei University School of Medicine
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- KOJIMA Michio
- The First Department of Internal Medicine, Jikei University School of Medicine
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- OGURA Kazuo
- The First Department of Internal Medicine, Jikei University School of Medicine
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- KAWASE Harumichi
- The First Department of Internal Medicine, Jikei University School of Medicine
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- KIMURA Kazuo
- The First Department of Internal Medicine, Jikei University School of Medicine
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- YAMAUCHI Masayoshi
- The First Department of Internal Medicine, Jikei University School of Medicine
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- KAMEDA Haruo
- The First Department of Internal Medicine, Jikei University School of Medicine
書誌事項
- タイトル別名
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- Studies on the Mechanisms of Serum Gamm
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抄録
With a view to elucidate the underlying mechanisms of serum γ-glutamyl transpeptidase (γ-GTP) elevation in various clinical hepatobiliary diseases, the characteristics of the activity changes in serum and hepatic γ-GTP were studied on rats with experimental models of liver injuries. γ-GTP in the liver was localized mainly in the microsomal fraction of the parenchymal cells and was gradually induced in the course of chronic liver injury with a consequent rise in the serum activity, whereas in acute liver damage, both serum and hepatic γ-GTP levels remained within the normal limits. On ligation of the common bile duct, the activity of serum γ-GTP was elevated with consistently normal concentration of the hepatic enzyme, thus suggesting that the enzyme is normally excreted into intestine via biliary system. Neither serum γ-GTP nor the hepatic enzyme activity was elevated in rats with regenerating liver or fatty liver. Morris' hepatoma-bearing rats showed a marked increase in serum γ-GTP as well as in the particle-bound enzyme in the implanted tumor cells whilst the enzyme in the host liver remained within the normal limits, thereby indicating the rise in serum γ-GTP activity to be derived from tumor cells. In the alcoholic liver γ-GTP showed dose-related increase in some extent, while with dosage over 6gm/kg the specific activity of the hepatic enzyme diminished without any significant alteration in the serum activity.
収録刊行物
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- Japanese Journal of Medicine
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Japanese Journal of Medicine 16 (1), 14-23, 1977
社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204866871424
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- NII論文ID
- 130004902940
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- NII書誌ID
- AA00691133
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- ISSN
- 1881123X
- 00215120
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- NDL書誌ID
- 1803996
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可