Takayasu Myocarditis Mediated by Cytotoxic T Lymphocytes

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  • TAKEDA Norifumi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • TAKAHASHI Toshiyuki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • SEKO Yoshinori
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • MAEMURA Koji
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • NAKASONE Hideki
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • SAKAMOTO Kei
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • HIRATA Yasunobu
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
  • NAGAI Ryozo
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine

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Description

A 15-year-old Japanese man was referred for evaluation of heart failure. Conventional heart failure therapy had little effect, and severe left ventricular dysfunction as well as elevated erythrocyte sedimentation rate persisted. Magnetic resonance angiography showed aortic dilatation with wall thickening characteristic of Takayasu′s arteritis. An endomyocardial biopsy specimen revealed infiltration of natural killer cells and γδ T lymphocytes, which play major roles in vascular injury of Takayasu′s arteritis. Prednisolone administration provided great benefits to cardiac function. These findings suggest that autoimmune cytotoxic mechanisms similar to those in arterial tissue may contribute to cardiac impairment in Takayasu′s arteritis.

Journal

  • Internal Medicine

    Internal Medicine 44 (3), 256-260, 2005

    The Japanese Society of Internal Medicine

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