Hemodynamic Alterations Following Infusion of Angiotensin II Analogue in Normal Subjects
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- YAMAMOTO Toshihide
- Endocrine Laboratory, Center for Adult Diseases
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- OGIHARA Toshio
- Department of Medicine and Geriatrics, Osaka University Medical School
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- HATA Takeshi
- Department of Medicine and Geriatrics, Osaka University Medical School
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- ICHIHARA Kiyoshi
- Department of Medicine and Geriatrics, Osaka University Medical School
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- KUAMHARA Yuichi
- Department of Medicine and Geriatrics, Osaka University Medical School
書誌事項
- タイトル別名
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- Hemodynamic Alterations Following Infus
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抄録
Changes of blood pressure (BP), creatinine clearance (Ccreat), plasma renin activity (PRA), plasma aldosterone concentration (PAC) and urinary excretion of adrenaline and noradrenaline (uAD, uNAD) were studied in 5 normal subjects following i. v. infusion of 1-sarcosine, 8-isoleucine angiotensin II (sar1, ile8-A II) and angiotensin II (A II). The effects of variable sodium balance on these changes were studied as well. Sar1, ile8-A II demonstrated variable agonistic activities at 4 sites of A II action, i.e., Ccreat, PRA and PAC. There seemed to be a reciprocal relation between agonistic and antagonistic activities (latter being evaluated by antagonism against A II-induced changes of BP, Ccreat, PRA and PAC) of sar1, ile8-A II at each of sites, which would rather suggest similarity than heterogeneity of A II receptors at these sites. It was disclosed that agonistis activities on BP, PRA and PAC were dependent on sodium balance, i.e., most agonistic during sodium repletion and least active during sodium depletion. The implications of these findings were discussed.
収録刊行物
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- Japanese Journal of Medicine
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Japanese Journal of Medicine 16 (2), 112-116, 1977
社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204867245696
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- NII論文ID
- 130003513493
- 40005320303
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- NII書誌ID
- AA00691133
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- ISSN
- 1881123X
- 00215120
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- NDL書誌ID
- 1819950
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可