Distribution of JC Virus DNA in Peripheral Blood Lymphocytes of Hematological Disease Cases.

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  • SHIMIZU Naoko
    The Second Department of Internal Medicine, Aichi Medical University
  • IMAMURA Akira
    The Second Department of Internal Medicine, Aichi Medical University
  • DAIMARU Osami
    The Second Department of Internal Medicine, Aichi Medical University
  • MIHARA Hidetsugu
    The Second Department of Internal Medicine, Aichi Medical University
  • KATO Yoshiro
    The Second Department of Internal Medicine, Aichi Medical University
  • KATO Ryoichi
    The Second Department of Internal Medicine, Aichi Medical University
  • OGURI Takashi
    The Second Department of Internal Medicine, Aichi Medical University
  • FUKADA Masako
    Department of Microbiology and Immunology, Aichi Medical University
  • YOKOCHI Takashi
    Department of Microbiology and Immunology, Aichi Medical University
  • YOSHIKAWA Kazuhiro
    The Second Department of Pathology, Aichi Medical University
  • KOMATSU Hirokazu
    The Second Department of Internal Medicine, Nagoya City University Medical School
  • UEDA Ryuzo
    The Second Department of Internal Medicine, Nagoya City University Medical School
  • NITTA Masakazu
    The Second Department of Internal Medicine, Aichi Medical University

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Abstract

Objective The distribution of JC virus DNA in peripheral blood was surveyed by the polymerase chain reaction using the late genes as markers. Results Six out of 52 cases of hematological diseases and one systemic lupus erythematosus case out of 17 cases were positive for JCV DNA. After separation into B and T lymphocytes by a cell sorter, JCV DNA was found in both cell types prepared from adult T cell leukemia and PML patients. Conclusion Only 1 or 2 copies of JCV genome were calculated to exist in a cell based on the time course analysis of PCR. Only B lymphocytes and glial brain cells are known to produce nuclear factors which support the growth of the virus. The result that B lymphocytes contained a copy number of JCV genome similar to T lymphocytes suggests that there is some barrier to viral growth in susceptible B lymphocytes, and that the growth of JCV is different from that of other virulent viruses.<br>(Internal Medicine 38: 932-937, 1999)

Journal

  • Internal Medicine

    Internal Medicine 38 (12), 932-937, 1999

    The Japanese Society of Internal Medicine

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