Distribution of JC Virus DNA in Peripheral Blood Lymphocytes of Hematological Disease Cases.
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- SHIMIZU Naoko
- The Second Department of Internal Medicine, Aichi Medical University
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- IMAMURA Akira
- The Second Department of Internal Medicine, Aichi Medical University
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- DAIMARU Osami
- The Second Department of Internal Medicine, Aichi Medical University
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- MIHARA Hidetsugu
- The Second Department of Internal Medicine, Aichi Medical University
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- KATO Yoshiro
- The Second Department of Internal Medicine, Aichi Medical University
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- KATO Ryoichi
- The Second Department of Internal Medicine, Aichi Medical University
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- OGURI Takashi
- The Second Department of Internal Medicine, Aichi Medical University
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- FUKADA Masako
- Department of Microbiology and Immunology, Aichi Medical University
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- YOKOCHI Takashi
- Department of Microbiology and Immunology, Aichi Medical University
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- YOSHIKAWA Kazuhiro
- The Second Department of Pathology, Aichi Medical University
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- KOMATSU Hirokazu
- The Second Department of Internal Medicine, Nagoya City University Medical School
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- UEDA Ryuzo
- The Second Department of Internal Medicine, Nagoya City University Medical School
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- NITTA Masakazu
- The Second Department of Internal Medicine, Aichi Medical University
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Abstract
Objective The distribution of JC virus DNA in peripheral blood was surveyed by the polymerase chain reaction using the late genes as markers. Results Six out of 52 cases of hematological diseases and one systemic lupus erythematosus case out of 17 cases were positive for JCV DNA. After separation into B and T lymphocytes by a cell sorter, JCV DNA was found in both cell types prepared from adult T cell leukemia and PML patients. Conclusion Only 1 or 2 copies of JCV genome were calculated to exist in a cell based on the time course analysis of PCR. Only B lymphocytes and glial brain cells are known to produce nuclear factors which support the growth of the virus. The result that B lymphocytes contained a copy number of JCV genome similar to T lymphocytes suggests that there is some barrier to viral growth in susceptible B lymphocytes, and that the growth of JCV is different from that of other virulent viruses.<br>(Internal Medicine 38: 932-937, 1999)
Journal
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- Internal Medicine
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Internal Medicine 38 (12), 932-937, 1999
The Japanese Society of Internal Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390001204867614336
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- NII Article ID
- 10005531090
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- NII Book ID
- AA10827774
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- COI
- 1:CAS:528:DC%2BD3cXhtlyksbk%3D
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 4943720
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- PubMed
- 10628929
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed