Hyperprolactinemia in Optico-spinal Multiple Sclerosis.

DOI Web Site Web Site PubMed 被引用文献2件 参考文献17件
  • YAMASAKI Kenji
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • HORIUCHI Izumi
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • MINOHARA Motozumi
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • OSOEGAWA Manabu
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • KAWANO Yuji
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • OHYAGI Yasumasa
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • YAMADA Takeshi
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
  • KIRA Jun-ichi
    the Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University

この論文をさがす

抄録

Objective To clarify the clinical features of MS patients with hyperprolactinemia.<br> Subjects and Methods The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay.<br> Results In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients.<br> Conclusion Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.<br>(Internal Medicine 39: 296-299, 2000)

収録刊行物

  • Internal Medicine

    Internal Medicine 39 (4), 296-299, 2000

    一般社団法人 日本内科学会

被引用文献 (2)*注記

もっと見る

参考文献 (17)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ