Chinese Herbs and Bone Disease
-
- HOSHINO Junichi
- Kidney Center, Toranomon Hospital
-
- UBARA Yoshifumi
- Kidney Center, Toranomon Hospital
-
- TAGAMI Tetsuo
- Kidney Center, Toranomon Hospital
-
- SAWA Naoki
- Kidney Center, Toranomon Hospital
-
- YOKOTA Masafumi
- Kidney Center, Toranomon Hospital
-
- KATORI Hideyuki
- Kidney Center, Toranomon Hospital
-
- TAKEMOTO Fumi
- Kidney Center, Toranomon Hospital
-
- MIKAMI Yoshihisa
- Department of Orthopedics, Toranomon Hospital
-
- HARA Shigeo
- Department of Pathology, Toranomon Hospital
-
- HARA Shigeko
- Kidney Center, Toranomon Hospital
Search this article
Abstract
We treated a patient with an unusual bone disease at least partly associated with Chinese herbs. Seven years after 65-year-old man had begun to consume Chinese herbs, multifocal osteoarthralgias were noted, and the patient was hospitalized for renal dysfunction (serum creatinine, 2.8 mg/dl; urea nitrogen, 19 mg/dl). Fanconi syndrome also was apparent. A renal biopsy specimen showed tubulo-interstitial fibrosis. Chinese herbs were discontinued and prednisolone was started, but bone and joint pain as well as renal function gradually worsened. Four years later, creatinine was 9.0 mg/dl and alkaline phosphatase was 571 IU/l. As bone scintigraphy revealed localized asymmetric lesions, Paget's disease of bone was suspected at first. However, neither osteosclerosis nor hypertrophy was seen in radiographs. Based on a bone specimen histology we diagnosed as mixed-type renal osteodystrophy including osteomalacia and osteitis fibrosa. Mosaic pattern of cement lines was not present. This case was not compatible with either Paget's disease or typical renal osteodystrophy as seen in dialysis patients. Etidronate disodium was effective in alleviating bone symptoms. The patient's bone disorder may be a new disease at least partly related to Chinese herbs independently of nephropathy.<br>(Internal Medicine 42: 345-350, 2003)
Journal
-
- Internal Medicine
-
Internal Medicine 42 (4), 345-350, 2003
The Japanese Society of Internal Medicine
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204867949952
-
- NII Article ID
- 130000767101
-
- NII Book ID
- AA10827774
-
- COI
- 1:STN:280:DC%2BD3s3gvVWjsA%3D%3D
-
- ISSN
- 13497235
- 09182918
-
- NDL BIB ID
- 6515686
-
- PubMed
- 12729324
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed