Coregulator-Related Diseases
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- YANASE Toshihiko
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
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- ADACHI Masahiro
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
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- GOTO Kiminobu
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
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- TAKAYANAGI Ryoichi
- Department of Geriatric Medicine, Graduate School of Medical Science, Kyushu University
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- NAWATA Hajime
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
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Description
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new “coregulator disease” concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.
Journal
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- Internal Medicine
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Internal Medicine 43 (5), 368-373, 2004
The Japanese Society of Internal Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390001204868172928
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- NII Article ID
- 10013090874
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- NII Book ID
- AA10827774
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- COI
- 1:CAS:528:DC%2BD2cXms1yntLk%3D
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 6953240
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- PubMed
- 15206547
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed