QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment

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  • NAKAMAE Hirohisa
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
  • TSUMURA Kei
    Division of Cardiology, Graduate School of Medicine, Osaka City University
  • AKAHORI Mika
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
  • TERADA Yoshiki
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
  • YAMANE Takahisa
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
  • HAYASHI Takeo
    Fukuda Denshi Co., Ltd.
  • SAITO Ikuko
    Fukuda Denshi Co., Ltd.
  • KANEKO Mutsuo
    Fukuda Denshi Co., Ltd.
  • OKAMOTO Noboru
    Aichi Sannomaru Hospital
  • ICHIHARA Yoshio
    Higashi Municipal Hospital of Nagoya
  • OHTA Kensuke
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
  • HINO Masayuki
    Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University

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  Objective  The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.<BR>  Methods  We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.<BR>  Patients  Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.<BR>  Results  LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD (r=0.35, p<0.01, r=0.43, p<0.01). Also left ventricular ejection fraction of (LVEF) or fractional shortening had a significant negative correlation to QTcD (r=−0.46, p<0.001, r=−0.27, p=0.02). The highest QTcD group had a significantly larger LV end-diastolic diameter or LV end-systolic diameter than the lowest QTcD [48.5±5.7 vs. 44.4±4.5 (mm), p<0.001, 34.1±6.4 vs. 28.8±4.3 (mm), p<0.001] and the highest QTcD group had a significantly lower LVEF than the lowest QTcD [57.5±8.0 vs. 65.5±6.4 (%), p<0.001]. On the other hand, none of the diastolic function markers were significantly correlated with QTcD.<BR>  Conclusion  We concluded that increased QTcD is correlated with LV dilation and systolic dysfunction induced by anthracycline therapy, and does not reflect a dispersion of ventricular repolarization or asynchronous motion.

収録刊行物

  • Internal Medicine

    Internal Medicine 43 (5), 379-387, 2004

    一般社団法人 日本内科学会

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