QT Dispersion Correlates with Systolic Rather than Diastolic Parameters in Patients Receiving Anthracycline Treatment
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- NAKAMAE Hirohisa
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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- TSUMURA Kei
- Division of Cardiology, Graduate School of Medicine, Osaka City University
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- AKAHORI Mika
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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- TERADA Yoshiki
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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- YAMANE Takahisa
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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- HAYASHI Takeo
- Fukuda Denshi Co., Ltd.
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- SAITO Ikuko
- Fukuda Denshi Co., Ltd.
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- KANEKO Mutsuo
- Fukuda Denshi Co., Ltd.
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- OKAMOTO Noboru
- Aichi Sannomaru Hospital
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- ICHIHARA Yoshio
- Higashi Municipal Hospital of Nagoya
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- OHTA Kensuke
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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- HINO Masayuki
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University
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説明
Objective The aim of this study was to investigate the relation of QT dispersion to left ventricular (LV) systolic and diastolic function in patients undergoing anthracycline therapy.<BR> Methods We used echocardiography to evaluate LV systolic and diastolic function and electrocardiography to evaluate QT dispersion and corrected QT dispersion (QTcD) in patients with hematological diseases, who received anthracycline therapy.<BR> Patients Seventy-two patients with hematological diseases who were receiving anthracycline treatment were enrolled in the present study.<BR> Results LV end-diastolic diameter or LV end-systolic diameter had a significant positive correlation to QTcD (r=0.35, p<0.01, r=0.43, p<0.01). Also left ventricular ejection fraction of (LVEF) or fractional shortening had a significant negative correlation to QTcD (r=−0.46, p<0.001, r=−0.27, p=0.02). The highest QTcD group had a significantly larger LV end-diastolic diameter or LV end-systolic diameter than the lowest QTcD [48.5±5.7 vs. 44.4±4.5 (mm), p<0.001, 34.1±6.4 vs. 28.8±4.3 (mm), p<0.001] and the highest QTcD group had a significantly lower LVEF than the lowest QTcD [57.5±8.0 vs. 65.5±6.4 (%), p<0.001]. On the other hand, none of the diastolic function markers were significantly correlated with QTcD.<BR> Conclusion We concluded that increased QTcD is correlated with LV dilation and systolic dysfunction induced by anthracycline therapy, and does not reflect a dispersion of ventricular repolarization or asynchronous motion.
収録刊行物
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- Internal Medicine
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Internal Medicine 43 (5), 379-387, 2004
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204868174592
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- NII論文ID
- 10013090926
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- NII書誌ID
- AA10827774
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- COI
- 1:CAS:528:DC%2BD2cXms1yntLc%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 6953254
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- PubMed
- 15206549
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可