Effect of Adenosine Triphosphate on Human Coronary Circulation.

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  • SHIODE Nobuo
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • KATO Masaya
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • NAKAYAMA Kensho
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • SHINOHARA Koichi
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • KUROKAWA Junichi
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • YAMAGATA Togo
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • MATSUURA Hideo
    The First Department of Internal Medicine, Hiroshima University School of Medicine
  • KAJIYAMA Goro
    The First Department of Internal Medicine, Hiroshima University School of Medicine

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  • Effect of Adenosine Triphosphate on Hum

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We investigated in humans the effects of adenosine triphosphate (ATP), administered by intracoronary bolus (4-16 μg) or intravenous infusion (25-200 μg/kg/min), on coronary and systemic hemodynamics and electrocardiogram (ECG) variables. All patients had normal epicardial coronary arteries. The maximal coronary blood flow velocity (CBFV) was determined with intracoronary bolus of papaverine. A 12 μg bolus of ATP (n=12) caused maximal coronary hyperemia similar to that caused by papaverine. Intracoronary boluses caused a small brief decrease in arterial pressure but no significant changes in HR or ECG variables. Intravenous infusion of ATP at 150 μg/kg/min (n=15) caused a decrease in the coronary resistance index similar to that caused by papaverine, but the rate of increase in CBFV by ATP was smaller than that caused by papaverine. No patients had a significant change in ECG variables, but some patients (40 %) had a serious decrease in arterial pressure. These studies suggest that maximal coronary vasodilation can be achieved safely with intracoronary ATP administration and that intravenous infusions at 150 μg/kg/min cause near-maximal coronary hyperemia in most patients.<br>(Internal Medicine 37: 818-825, 1998)

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  • Internal Medicine

    Internal Medicine 37 (10), 818-825, 1998

    一般社団法人 日本内科学会

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