Hypertension and Genes.
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- HIGAKI Jitsuo
- The Department of Geriatric Medicine, Osaka University Medical School
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- KATSUYA Tomohiro
- The Department of Geriatric Medicine, Osaka University Medical School
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- MORISHITA Ryuichi
- The Department of Geriatric Medicine, Osaka University Medical School
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- OGIHARA Toshio
- The Department of Geriatric Medicine, Osaka University Medical School
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Abstract
Under classical strategy, scientists have tried first to find a physiological phenomenon specific for essential hypertension, then to identify the protein underlying the physiological abnormality, and finally to clarify the causative gene which encoded the protein. On the other hand, under the reverse genetic approach, the correlation between hypertension and genetic abnormality is identified first, and then the pathogenesis is clarified-in reverse order. Therefore, it is not extraordinary for unexpected results to be obtained in the correlation between a gene and a disease, suggesting that this approach has a possibility to be a breakthrough in the chaos of hypertension research.
Journal
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- Internal Medicine
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Internal Medicine 40 (2), 144-147, 2001
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390001204868964480
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- NII Article ID
- 130000767826
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- NII Book ID
- AA10827774
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- COI
- 1:STN:280:DC%2BD3M3gvVSitQ%3D%3D
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- ISSN
- 13497235
- 09182918
- http://id.crossref.org/issn/09182918
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- NDL BIB ID
- 5682152
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- PubMed
- 11300149
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed