13-cis Retinoic Acid Inhibits Growth of Adult T Cell Leukemia Cells and Causes Apoptosis; Possible New Indication for Retinoid Therapy.

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  • MAEDA Yasuhiro
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • MIYATAKE Jun-ichi
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • SONO Hiroshi
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • MATSUDA Mitsuhiro
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • TATSUMI Yoichi
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • HORIUCHI Fusanari
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • IRIMAJIRI Kiyohiro
    The Third Department of Internal Medicine, Kinki University School of Medicine
  • HORIUCHI Atsushi
    The Third Department of Internal Medicine, Kinki University School of Medicine

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Abstract

We evaluated the effects of 13-cis retinoic acid (13-cis RA) on the growth of peripheral blood mononuclear cells (PBMC) obtained from 12 patients with adult T cell leukemia (ATL). In general, 13-cis RA potently inhibited the growth of PBMC from ATL patients. However, the sensitivity of the cells to 13-cis RA-induced growth inhibition varied among the patients. The ATL patients fell into three groups (hypersensitive, sensitive and resistant to 13-cis RA) according to the percent reduction of 3H-thymidine incorporation before and after treatment with 13-cis RA. Agarose gel electrophoresis of total genomic DNA from a patient sensitive to 13-cis RA provided evidence of the DNA fragmentation indicative of apoptosis. The ability of 13-cis RA to induce apoptosis in PBMC from ATL patients suggests that retinoids may be useful in the treatment of ATL.<br>(Internal Medicine 35:180-184, 1996)

Journal

  • Internal Medicine

    Internal Medicine 35 (3), 180-184, 1996

    The Japanese Society of Internal Medicine

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