Role of Hyperinsulinemia in Atherosclerotic Coronary Arterial Disease. Studies of Semi-quantitative Coronary Angiography.

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  • TSUCHIHASHI Kazufumi
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • HIKITA Nobuichi
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • HASE Mamoru
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • AGATA Jun
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SAITOH Shigeyuki
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • NAKATA Tomoaki
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • URA Nobuyuki
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SHIMAMOTO Kazuaki
    The Second Department of Internal Medicine, Sapporo Medical University School of Medicine

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Objective To evaluate the role of insulin resistance on coronary atherosclerosis, angiographic semiquantitative scores of coronary stenosis and calcification were evaluated. Subjects and Methods Ninety-five non-diabetic subjects with coronary arterial disease were selected from our angiographic data base. Hyperinsulinemia was defined as a serum insulin level of ≥60.4 IU/l at 120 minutes after 75 g oral glucose challenge. Results Twenty-three (24%) of the patients exhibited hyperinsulinemia. There was no difference in age or gender between the two subgroups. The incidence of hypertension, smoking habits, hypercholesterolemia, and hyperuricemia were also the same among the insulin resistance subgroups. Subjects with hyperinsulinemia had higher coronary artery scores of stenosis (11.9±5.6 vs 8.3±5.0, p<0.0001) and calcification (7.5±6.3 vs 4.8±4.9, p<0.0001). Moreover, the stenosis score had a close linear correlation with the 120 minutes serum insulin level (r=0.266, p=0.009), but not with the fasting level. Conclusion These results suggest that hyperinsulinemia is a risk for coronary arterial disease, and emphasize the severity of coronary atherosclerosis in normal glucose tolerant subjects.<br>(Internal Medicine 38: 691-697, 1999)

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  • Internal Medicine

    Internal Medicine 38 (9), 691-697, 1999

    一般社団法人 日本内科学会

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