IgA-.LAMBDA./IgG-.KAPPA. Biclonal Myeloma in which Two Clones Proliferated in Individual Sites.

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  • ANDO Keiko
    the First Department of Internal Medicine, Tokyo Medical University
  • YAGUCHI Makoto
    the First Department of Internal Medicine, Tokyo Medical University
  • OKABE Seiichi
    the First Department of Internal Medicine, Tokyo Medical University
  • MIYAZAWA Keisuke
    the First Department of Internal Medicine, Tokyo Medical University
  • OHYASHIKI Kazuma
    the First Department of Internal Medicine, Tokyo Medical University

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Other Title
  • IgA-λ/IgG-κ Biclonal Myeloma in which Two Clones Proliferated in Individual Sites
  • IgA ラムダ IgG カッパ Biclonal Myeloma in which Two Clones Proliferated in Individual Sites

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Description

A 72-year-old man was admitted to our hospital because of lumbago and numbness of legs. Tumor invasion at the fourth lumbar vertebra was revealed. Immunohistochemistry using specific antibodies against each heavy and light chain of immunoglobulin revealed that the myeloma cells in bone marrow were all IgA-λ type whereas they were all positive for IgG-κ type in a tumor of the fourth lumbar vertebra. These data indicate that the patient had IgG-κ/IgA-λ biclonal myeloma. Different phenotypes of M-proteins and distinct proliferating sites for two clones suggest that they may have resulted from two independent transforming events.<br>(Internal Medicine 39:170-175, 2000)

Journal

  • Internal Medicine

    Internal Medicine 39 (2), 170-175, 2000

    The Japanese Society of Internal Medicine

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