Serum Levels of KL-6 Reflect Disease Activity of Interstitial Pneumonia Associated with ANCA-related Vasculitis.
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- IWATA Yasunori
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- WADA Takashi
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- FURUICHI Kengo
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- KITAGAWA Kiyoki
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- KOKUBO Satoshi
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- KOBAYASHI Motoo
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- SAKAI Norihiko
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- YOSHIMOTO Keiichi
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- SHIMIZU Miho
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- KOBAYASHI Ken-ichi
- the Department of Gastroenterology and Nephrology, Kanazawa University
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- YOKOYAMA Hitoshi
- Division of Blood Purification, Kanazawa University
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Abstract
Objective KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.<br> Methods Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay.<br> Patients We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia.<br> Results Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis.<br> Conclusion These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis.<br>(Internal Medicine 40:1093-1097, 2001)
Journal
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- Internal Medicine
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Internal Medicine 40 (11), 1093-1097, 2001
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390001204869654656
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- NII Article ID
- 10007313731
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- NII Book ID
- AA11211604
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- ISSN
- 10806040
- 13497235
- 09182918
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- COI
- 1:CAS:528:DC%2BD38Xns1yrug%3D%3D
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- NDL BIB ID
- 5984647
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- PubMed
- 11757762
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed