Anti-neuronal Antibodies in Acute Pandysautonomia
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- Matsui Naoko
- Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Mitsui Takao
- Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima Department of Neurology, Tokushima National Hospital, National Hospital Organization
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- Ohshima Yasushi
- Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Yokoi Kenji
- Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Kunishige Makoto
- Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Yagi Fumikazu
- Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Vernino Steven
- Department of Neurology, University of Texas Southwestern Medical Center
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- Matsumoto Toshio
- Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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- Kaji Ryuji
- Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
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Description
We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intravenous immunoglobulin therapy. Thin-layer chromatography (TLC)-immunostaining did not demonstrate any antibodies against gangliosides, but immunoblot analysis showed antibodies against a neuroblastoma cell line, SH-SY5Y, in serum samples. Furthermore, ganglionic acetylcholine receptor autoantibodies were detected in one patient. These findings suggest that neuronal antibodies against the autonomic nervous system play an important role in the pathogenesis of acute pandysautonomia.<br>
Journal
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- Internal Medicine
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Internal Medicine 49 (1), 73-77, 2010
The Japanese Society of Internal Medicine